Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
04
09
2018
accepted:
01
02
2019
pubmed:
6
3
2019
medline:
28
12
2019
entrez:
6
3
2019
Statut:
ppublish
Résumé
Adenoviral vectors can induce T and B cell immune responses to Ags encoded in the recombinant vector. The MHC class II invariant chain (Ii) has been used as an adjuvant to enhance T cell responses to tethered Ag encoded in adenoviral vectors. In this study, we modified the Ii adjuvant by insertion of a furin recognition site (Ii-fur) to obtain a secreted version of the Ii. To test the capacity of this adjuvant to enhance immune responses, we recombined vectors to encode
Identifiants
pubmed: 30833346
pii: jimmunol.1801210
doi: 10.4049/jimmunol.1801210
pmc: PMC6452028
doi:
Substances chimiques
Antibodies, Protozoan
0
Histocompatibility Antigens Class II
0
Malaria Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2320-2331Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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