Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus.
Animals
Animals, Newborn
Autism Spectrum Disorder
/ chemically induced
Benzhydryl Compounds
/ toxicity
Disease Models, Animal
Female
Forkhead Transcription Factors
/ metabolism
Gene Expression Regulation, Developmental
/ drug effects
Hippocampus
/ drug effects
Humans
Male
Phenols
/ toxicity
Pregnancy
Prenatal Exposure Delayed Effects
/ chemically induced
RNA-Seq
Rats
Sex Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 02 2019
28 02 2019
Historique:
received:
06
09
2018
accepted:
21
01
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
22
9
2020
Statut:
epublish
Résumé
Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related genes in the developing brain remains unclear. In this study, transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed to BPA was conducted and revealed a list of differentially expressed genes (DEGs) associated with ASD. Among the DEGs, several ASD candidate genes, including Auts2 and Foxp2, were dysregulated and showed sex differences in response to BPA exposure. The interactome and pathway analyses of DEGs using Ingenuity Pathway Analysis software revealed significant associations between the DEGs in males and neurological functions/disorders associated with ASD. Moreover, the reanalysis of transcriptome profiling data from previously published BPA studies consistently showed that BPA-responsive genes were significantly associated with ASD-related genes. The findings from this study indicate that prenatal BPA exposure alters the expression of ASD-linked genes in the hippocampus and suggest that maternal BPA exposure may increase ASD susceptibility by dysregulating genes associated with neurological functions known to be negatively impacted in ASD, which deserves further investigations.
Identifiants
pubmed: 30816183
doi: 10.1038/s41598-019-39386-w
pii: 10.1038/s41598-019-39386-w
pmc: PMC6395584
doi:
Substances chimiques
Benzhydryl Compounds
0
Forkhead Transcription Factors
0
Foxp2 protein, rat
0
Phenols
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3038Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES023061
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028124
Pays : United States
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