Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
received:
10
01
2019
accepted:
20
02
2019
pubmed:
26
2
2019
medline:
18
12
2019
entrez:
27
2
2019
Statut:
ppublish
Résumé
Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several studies have provided important insights, particularly regarding the role of arsenic trioxide (ATO) in frontline therapy. Ten years later, a European LeukemiaNet expert panel has reviewed the recent advances in the management of APL in both frontline and relapse settings in order to develop updated evidence- and expert opinion-based recommendations on the management of this disease. Together with providing current indications on genetic diagnosis, modern risk-adapted frontline therapy, and salvage treatment, the review contains specific recommendations for the identification and management of the most important complications such as the bleeding disorder APL differentiation syndrome, QT prolongation, and other all-
Identifiants
pubmed: 30803991
pii: S0006-4971(20)42634-5
doi: 10.1182/blood-2019-01-894980
pmc: PMC6509567
doi:
Substances chimiques
Tretinoin
5688UTC01R
Arsenic Trioxide
S7V92P67HO
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1630-1643Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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