Effects of conditioned social fear on ethanol drinking and vice-versa in male mice.
Anxiety
CORT ELISA
Corticosterone
Ethanol drinking
Extinction
Locomotion
Social fear conditioning
Social investigation
Taste preference
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
26
09
2018
accepted:
13
02
2019
pubmed:
25
2
2019
medline:
5
11
2019
entrez:
25
2
2019
Statut:
ppublish
Résumé
Social anxiety disorder (SAD) is highly comorbid with alcohol use disorders, but the complex relationship between social fear and alcohol drinking is poorly understood due to the lack of specific animal models. We investigated whether social fear alters ethanol drinking under both stress-free and stress-inducing conditions and whether ethanol alleviates symptoms of social fear. We used the social fear conditioning (SFC) paradigm, an animal model with face and predictive validity to SAD, to induce specific social fear in male CD1 mice, i.e., without comorbid depression or anxiety-like behavior. Plasma corticosterone (CORT) levels were measured in conditioned (SFC We show that exposure to social but not non-social stimuli leads to higher plasma CORT levels in SFC These results have important clinical connotations as they suggest that voluntary ethanol drinking might specifically reverse symptoms of social fear in a SAD-relevant animal model.
Identifiants
pubmed: 30798401
doi: 10.1007/s00213-019-05199-y
pii: 10.1007/s00213-019-05199-y
doi:
Substances chimiques
Ethanol
3K9958V90M
Corticosterone
W980KJ009P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2059-2067Subventions
Organisme : Bundesministerium f?r Bildung und Forschung
ID : 01EE1401C
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