Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis.
Adolescent
Age Factors
Antitubercular Agents
/ pharmacology
Child
Child, Preschool
Coinfection
Extensively Drug-Resistant Tuberculosis
/ drug therapy
Female
Global Health
Humans
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests
Mycobacterium tuberculosis
/ drug effects
Population Surveillance
Treatment Failure
Treatment Outcome
MDR TB
TB
XDR TB
antimicrobial resistance
bacteria
children
extensively drug-resistant tuberculosis
global systematic review
meta-analysis
mortality
multidrug-resistant TB
outcomes
respiratory infections
treatment outcomes
tuberculosis
tuberculosis and other mycobacteria
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
entrez:
22
2
2019
pubmed:
23
2
2019
medline:
16
8
2019
Statut:
ppublish
Résumé
Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999-2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required.
Identifiants
pubmed: 30789141
doi: 10.3201/eid2503.180852
pmc: PMC6390755
doi:
Substances chimiques
Antitubercular Agents
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Pagination
441-450Subventions
Organisme : Medical Research Council
ID : MR/M007340/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R007942/1
Pays : United Kingdom
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