Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem.
acute kidney injury
cefepime
meropenem
piperacillin-tazobactam
vancomycin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
20
12
2018
accepted:
13
02
2019
pubmed:
21
2
2019
medline:
31
3
2020
entrez:
21
2
2019
Statut:
epublish
Résumé
Critically ill patients are frequently treated with empirical antibiotic therapy, including vancomycin and β-lactams. Recent evidence suggests an increased risk of acute kidney injury (AKI) in patients who received a combination of vancomycin and piperacillin-tazobactam (VPT) compared with patients who received vancomycin alone or vancomycin in combination with cefepime (VC) or meropenem (VM), but most studies were conducted predominately in the non-critically ill population. A retrospective cohort study that included 2,492 patients was conducted in the intensive care units of a large university hospital with the primary outcome being the development of any AKI. The rates of any AKI, as defined by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, were 39.3% for VPT patients, 24.2% for VC patients, and 23.5% for VM patients (
Identifiants
pubmed: 30782987
pii: AAC.02658-18
doi: 10.1128/AAC.02658-18
pmc: PMC6496064
pii:
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Cefepime
807PW4VQE3
Meropenem
FV9J3JU8B1
Tazobactam
SE10G96M8W
Piperacillin
X00B0D5O0E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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