Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice.

Animals Benzaldehydes / pharmacology DNA Damage / drug effects Flavoring Agents / pharmacology Fungicides, Industrial / toxicity Liver / drug effects Male Maneb / toxicity Mice Oxidative Stress / drug effects Protective Agents / pharmacology
DNA fragmentation Vanillin liver maneb oxidative stress

Journal

Human & experimental toxicology
ISSN: 1477-0903
Titre abrégé: Hum Exp Toxicol
Pays: England
ID NLM: 9004560

Informations de publication

Date de publication:
Jun 2019
Historique:
pubmed: 21 2 2019
medline: 3 1 2020
entrez: 21 2 2019
Statut: ppublish

Résumé

Vanillin, a widely used flavoring agent, has antimutagenic and antioxidant properties. The current study was performed to evaluate its beneficial role against hepatotoxicity induced by maneb, a dithiocarbamate fungicide. Mice were divided into four groups of six each: group 1, serving as negative controls which received by intraperitoneal way only distilled water, a solvent of maneb; group 2, received daily, by intraperitoneal way, maneb (30 mg kg

Identifiants

DOI: 10.1177/0960327119831067 PMID: 30782018
pubmed: 30782018
doi: 10.1177/0960327119831067
doi:

Substances chimiques

Benzaldehydes 0
Flavoring Agents 0
Fungicides, Industrial 0
Protective Agents 0
Maneb 12427-38-2
vanillin CHI530446X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

619-631

Auteurs

M Sefi (M)

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.
2 Physiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia.
ORCID: 0000-0002-8624-5417

A Elwej (A)

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.

M Chaâbane (M)

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.

S Bejaoui (S)

2 Physiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia.

R Marrekchi (R)

3 Biochemistry Laboratory, Department of Biochemistry, CHU Hedi Chaker, University of Sfax, Sfax, Tunisia.

K Jamoussi (K)

3 Biochemistry Laboratory, Department of Biochemistry, CHU Hedi Chaker, University of Sfax, Sfax, Tunisia.

N Gouiaa (N)

4 Histopathology Laboratory, Department of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia.

T Boudawara-Sellemi (T)

4 Histopathology Laboratory, Department of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia.

M El Cafsi (M)

2 Physiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia.

N Zeghal (N)

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.

N Soudani (N)

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.
2 Physiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Composés chimiques organiques › Aldéhydes › Benzaldéhydes › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Phénomènes génétiques › Altération de l'ADN › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Aliments et boissons › Aliments › Ingrédients alimentaires › Additifs alimentaires › Aromatisants › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Actions chimiques et utilisations › Actions toxiques › Pesticides › Fongicides industriels › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Système digestif › Foie › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Composés chimiques organiques › Composés du soufre › Thiocarbamates › Éthylène-bis(dithiocarbamates) › Manèbe › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Beneficial role of vanillin, a polyphenolic...
Recherchemedicale.com › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Beneficial role of vanillin, a polyphenolic...