Offline impact of transcranial focused ultrasound on cortical activation in primates.

Animals Cerebral Cortex / physiology Macaca Magnetic Resonance Imaging Ultrasonography / methods
brain stimulation connectivity frontal lobe neuroimaging neuroscience resting-state fMRI rhesus macaque transcranial ultrasound stimulation

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
12 02 2019
Historique:
received: 28 07 2018
accepted: 26 01 2019
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 27 3 2020
Statut: epublish

Résumé

To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver on its full potential for research and therapy, ultrasound protocols are required that induce longer-lasting 'offline' changes. Here, we present a TUS protocol that modulates brain activation in macaques for more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity in brain areas reflects activity in interconnected regions but TUS caused stimulated areas to interact more selectively with the rest of the brain. In a within-subject design, we observe regionally specific TUS effects for two medial frontal brain regions - supplementary motor area and frontal polar cortex. Independently of these site-specific effects, TUS also induced signal changes in the meningeal compartment. TUS effects were temporary and not associated with microstructural changes.

Identifiants

DOI: 10.7554/eLife.40541 PMID: 30747105 PMC: PMC6372282
pubmed: 30747105
doi: 10.7554/eLife.40541
pii: 40541
pmc: PMC6372282
doi:
pii:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : G0902373
Pays : United Kingdom
Organisme : Wellcome
ID : 105238/Z/14/Z
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-10-EQPX-15
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H016902/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N019814/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600994
Pays : United Kingdom
Organisme : Wellcome
ID : 105651/Z/14/Z
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 452-13-015
Pays : International
Organisme : Medical Research Council
ID : MR/P024955/1
Pays : United Kingdom
Organisme : Wellcome
ID : 103184/Z/13/Z
Pays : International
Organisme : Wellcome
ID : WT100973AIA
Pays : International
Organisme : Wellcome
ID : 203139/Z/16/Z
Pays : International

Informations de copyright

© 2019, Verhagen et al.

Déclaration de conflit d'intérêts

LV, CG, DF, CC, DJ, HA, LR, MS, BA, SL, MK, KK, RM, MR, PP, JA, JS No competing interests declared

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Auteurs

Lennart Verhagen (L)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0003-3207-7929

Cécile Gallea (C)

Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Davide Folloni (D)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0003-1653-5969

Charlotte Constans (C)

Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
ORCID: 0000-0001-6378-9158

Daria Ea Jensen (DE)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

Harry Ahnine (H)

Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Léa Roumazeilles (L)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

Mathieu Santin (M)

Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Bashir Ahmed (B)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

Stéphane Lehericy (S)

Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Miriam C Klein-Flügge (MC)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0002-5156-9833

Kristine Krug (K)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0001-7119-9350

Rogier B Mars (RB)

Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.

Matthew Fs Rushworth (MF)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

Pierre Pouget (P)

Institute du Cerveau et de la Moelle épinière (ICM), UMRS 975 INSERM, CNRS 7225, UMPC, Paris, France.
ORCID: 0000-0002-4721-7376

Jean-François Aubry (JF)

Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris, France.
ORCID: 0000-0003-2644-3945

Jerome Sallet (J)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0002-7878-0209

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Offline impact of transcranial focused...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Offline impact of transcranial focused...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Offline impact of transcranial focused...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Offline impact of transcranial focused...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Offline impact of transcranial focused...