Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors.
asymmetric catalysis
cystine-glutamate exchanger
dehydroamino acids
diaminosuberic acids
hydrogenation
orthogonal protection
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
19
01
2019
pubmed:
13
2
2019
medline:
13
2
2019
entrez:
13
2
2019
Statut:
ppublish
Résumé
Catalytic asymmetric hydrogenation of dehydroamino acid esters with biscarbamate protection was examined for the first time to prepare optically active amino acids. The new method was successfully applied to the synthesis of new cystine-glutamate exchanger inhibitors.
Identifiants
pubmed: 30746782
doi: 10.1002/chem.201900289
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5145-5148Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17K08216
Organisme : Japan Society for the Promotion of Science
ID : 16H01166
Organisme : Japan Society for the Promotion of Science
ID : 18H04433
Organisme : Japan Society for the Promotion of Science
ID : 18K14345
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.