A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
07
08
2018
accepted:
22
01
2019
entrez:
10
2
2019
pubmed:
10
2
2019
medline:
9
4
2019
Statut:
epublish
Résumé
Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural analyses, molecular dynamics simulations, resonance energy transfer-based approaches and mutagenesis, we identify a conserved basic amino acid in TM6 in Class F receptors that acts as a molecular switch to mediate receptor activation. Across all tested Class F receptors (FZD
Identifiants
pubmed: 30737406
doi: 10.1038/s41467-019-08630-2
pii: 10.1038/s41467-019-08630-2
pmc: PMC6368630
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
667Subventions
Organisme : NIGMS NIH HHS
ID : F30 GM131672
Pays : United States
Organisme : Medical Research Council
ID : MC_U105185859
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM130142
Pays : United States
Références
Nat Rev Drug Discov. 2002 Aug;1(8):599-608
pubmed: 12402500
Nat Commun. 2014 Jul 10;5:4355
pubmed: 25008467
Cancer Res. 2013 Jan 15;73(2):502-7
pubmed: 23188502
Elife. 2018 May 04;7:
pubmed: 29726815
J Pharmacol Exp Ther. 2011 Feb;336(2):296-302
pubmed: 21030484
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
Methods Mol Biol. 2015;1322:35-44
pubmed: 26179037
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Trends Biochem Sci. 2014 Dec;39(12):594-602
pubmed: 25458114
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Nature. 2000 Aug 31;406(6799):1005-9
pubmed: 10984056
Methods Mol Biol. 2014;1137:1-15
pubmed: 24573470
Nature. 2013 May 16;497(7449):338-43
pubmed: 23636324
Mol Pharmacol. 2016 Oct;90(4):447-59
pubmed: 27458145
Bioinformatics. 2007 Nov 1;23(21):2947-8
pubmed: 17846036
Nature. 2016 Jul 7;535(7610):182-6
pubmed: 27362234
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Drug Discov Today. 2012 Dec;17(23-24):1316-22
pubmed: 22819927
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Nature. 2001 May 17;411(6835):349-54
pubmed: 11357142
Nat Commun. 2014;5:3309
pubmed: 24525480
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nat Rev Cancer. 2013 Jun;13(6):412-24
pubmed: 23640210
Sci Signal. 2018 Dec 04;11(559):
pubmed: 30514810
Nature. 2016 Jul 28;535(7613):517-522
pubmed: 27437577
J Biol Chem. 1980 Aug 10;255(15):7108-17
pubmed: 6248546
PLoS One. 2017 Apr 20;12(4):e0175642
pubmed: 28426733
Nature. 2008 Dec 18;456(7224):967-70
pubmed: 18987629
BMC Bioinformatics. 2006 Aug 16;7:382
pubmed: 16914055
Nature. 2018 Mar 1;555(7694):121-125
pubmed: 29466332
Nat Rev Mol Cell Biol. 2009 Jul;10(7):468-77
pubmed: 19536106
Mol Cell Biol. 2004 Mar;24(5):2000-11
pubmed: 14966280
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
Pharmacol Ther. 1998 Dec;80(3):231-64
pubmed: 9888696
Nat Commun. 2017 Aug 9;8(1):226
pubmed: 28790300
Cell. 2018 Jul 12;174(2):312-324.e16
pubmed: 29804838
Nature. 1998 Jan 1;391(6662):90-2
pubmed: 9422511
Pharmacol Rev. 2010 Dec;62(4):632-67
pubmed: 21079039
J Comput Chem. 2005 Dec;26(16):1781-802
pubmed: 16222654
Nature. 2016 Aug 4;536(7614):104-7
pubmed: 27462812
Cell Signal. 2017 Apr;32:93-103
pubmed: 28126591
J Biol Chem. 2018 Nov 30;293(48):18477-18493
pubmed: 30309985
J Biol Chem. 2014 Aug 22;289(34):23520-33
pubmed: 24993822
Nature. 2016 Aug 25;536(7617):484-7
pubmed: 27525504
Cell. 2012 Sep 28;151(1):14-23
pubmed: 23021212
FASEB J. 2014 May;28(5):2293-305
pubmed: 24500924
Cell Signal. 2014 Sep;26(9):1943-9
pubmed: 24873871
Nature. 2018 Aug;560(7720):666-670
pubmed: 30135577
J Biol Chem. 2018 May 11;293(19):7466-7473
pubmed: 29523687
Nat Commun. 2017 May 17;8:15383
pubmed: 28513578
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20
pubmed: 22411803
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Biophys J. 2009 Jul 8;97(1):50-8
pubmed: 19580743
Science. 2018 Aug 17;361(6403):
pubmed: 30026314
Nat Struct Mol Biol. 2018 Feb;25(2):185-194
pubmed: 29335563
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18684-9
pubmed: 22031696
Nature. 2018 Jun;558(7711):620-623
pubmed: 29925951
Biochem Pharmacol. 2016 Oct 15;118:68-87
pubmed: 27569426
Trends Pharmacol Sci. 2018 Sep;39(9):828-842
pubmed: 30049420
Curr Med Chem. 2012;19(8):1090-109
pubmed: 22300046
J Biol Chem. 2004 Apr 9;279(15):14879-88
pubmed: 14747478
J Biol Chem. 2015 Mar 13;290(11):6789-98
pubmed: 25605717
Mol Pharmacol. 2013 Mar;83(3):691-7
pubmed: 23292797
Cell Signal. 2010 May;22(5):717-27
pubmed: 20006983
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11354-8
pubmed: 1662393
Curr Opin Struct Biol. 2011 Aug;21(4):567-72
pubmed: 21782416
Cell Res. 2005 Jan;15(1):28-32
pubmed: 15686623
Acta Physiol (Oxf). 2011 Nov;203(3):363-72
pubmed: 21557822
Nat Cell Biol. 2011 Dec 18;14(2):186-91
pubmed: 22179044
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6
pubmed: 12391318
Development. 2009 Oct;136(19):3205-14
pubmed: 19736321
Cell Signal. 2011 Mar;23(3):550-4
pubmed: 21070854
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12607-12
pubmed: 16885213
J Neuroinflammation. 2012 May 30;9:111
pubmed: 22647544
Nat Methods. 2017 Jan;14(1):71-73
pubmed: 27819658
Annu Rev Biochem. 2018 Jun 20;87:897-919
pubmed: 29925258
J Comput Chem. 2013 Sep 30;34(25):2135-45
pubmed: 23832629
J Biol Chem. 2001 Aug 3;276(31):29171-7
pubmed: 11375997
Genes Cells. 2004 Jan;9(1):49-58
pubmed: 14723707
Nature. 2008 Sep 25;455(7212):497-502
pubmed: 18818650
Cell Signal. 2017 Oct;38:85-96
pubmed: 28668722