Assessment of a storage system to deliver uninterrupted therapeutic oxygen during power outages in resource-limited settings.
Developing Countries
Drug Storage
/ methods
Emergencies
Equipment and Supplies, Hospital
Feasibility Studies
Health Resources
/ supply & distribution
Humans
Medication Systems, Hospital
Oxygen
/ administration & dosage
Pneumonia
/ therapy
Reproducibility of Results
Tertiary Care Centers
/ organization & administration
Uganda
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
04
2018
accepted:
07
01
2019
entrez:
7
2
2019
pubmed:
7
2
2019
medline:
14
11
2019
Statut:
epublish
Résumé
Access to therapeutic oxygen remains a challenge in the effort to reduce pneumonia mortality among children in low- and middle-income countries. The use of oxygen concentrators is common, but their effectiveness in delivering uninterrupted oxygen is gated by reliability of the power grid. Often cylinders are employed to provide continuous coverage, but these can present other logistical challenges. In this study, we examined the use of a novel, low-pressure oxygen storage system to capture excess oxygen from a concentrator to be delivered to patients during an outage. A prototype was built and tested in a non-clinical trial in Jinja, Uganda. The trial was carried out at Jinja Regional Referral Hospital over a 75-day period. The flow rate of the unit was adjusted once per week between 0.5 and 5 liters per minute. Over the trial period, 1284 power failure episodes with a mean duration of 3.1 minutes (range 0.08 to 1720 minutes) were recorded. The low-pressure system was able to deliver oxygen over 56% of the 4,295 power outage minutes and cover over 99% of power outage events over the course of the study. These results demonstrate the technical feasibility of a method to extend oxygen availability and provide a basis for clinical trials.
Identifiants
pubmed: 30726247
doi: 10.1371/journal.pone.0211027
pii: PONE-D-18-12385
pmc: PMC6364892
doi:
Substances chimiques
Oxygen
S88TT14065
Banques de données
Dryad
['10.5061/dryad.5m66621']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0211027Déclaration de conflit d'intérêts
The commercial affiliation with The Global Good Fund I, LLC (www.globalgood.com) does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
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