The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063).

Adult Anti-HIV Agents / therapeutic use Brazil / epidemiology Depression / psychology Drug Users Female HIV Infections / drug therapy HIV-1 / drug effects Heterosexuality / psychology Homosexuality, Male / psychology Humans Longitudinal Studies Male Medication Adherence / psychology Middle Aged Substance-Related Disorders / complications Thailand / epidemiology Viral Load Young Adult Zambia / epidemiology
Adherence Depression HIV Substance use Undetectable viral load

Journal

AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133

Informations de publication

Date de publication:
Mar 2019
Historique:
pubmed: 7 2 2019
medline: 17 4 2019
entrez: 7 2 2019
Statut: ppublish

Résumé

The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association. In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02). In Brazil, alcohol misuse by MSM was associated with decreased odds of undetectable VL (AOR = 0.34; 95% CI 0.13, 0.92, p = 0.03). Polysubstance use by heterosexual men in Brazil was associated with decreased odds of ART adherence (AOR = 0.25; 95% CI 0.08, 0.78, p = 0.02). VL suppression appears attainable among non-injection substance users. Substance use interventions among HIV-positive men should address depression, adherence, and VL undetectability.

Identifiants

DOI: 10.1007/s10461-019-02415-w PMID: 30725397 PMC: PMC6414080
pubmed: 30725397
doi: 10.1007/s10461-019-02415-w
pii: 10.1007/s10461-019-02415-w
pmc: PMC6414080
mid: NIHMS1520937
doi:

Substances chimiques

Anti-HIV Agents 0

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

649-660

Subventions

Organisme : NIMH NIH HHS
ID : K01 MH111374
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD077891
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD077891-04S1
Organisme : NIMH NIH HHS
ID : K01MH111374
Pays : United States
Organisme : NIMHD NIH HHS
ID : L60MD011184
Pays : United States
Organisme : NIDA NIH HHS
ID : K24 DA040489
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI069424
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA023356
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068619
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH083617
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH058107
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069412
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA025009
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI069412
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068617
Pays : United States
Organisme : NIMHD NIH HHS
ID : L60 MD011184
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH083620
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069424
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01AA025009
Pays : United States
Organisme : NIDA NIH HHS
ID : 9K24DA040489
Pays : United States

Références

Clin Diagn Lab Immunol. 2000 Jan;7(1):96-100
pubmed: 10618285
J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):396-404
pubmed: 10866232
Am J Psychiatry. 2001 May;158(5):725-30
pubmed: 11329393
J Acquir Immune Defic Syndr. 2001 Jul 1;27(3):251-9
pubmed: 11464144
Arch Gen Psychiatry. 2001 Aug;58(8):721-8
pubmed: 11483137
J Gen Intern Med. 2002 May;17(5):377-81
pubmed: 12047736
AIDS Care. 2003 Dec;15(6):775-85
pubmed: 14617499
J Infect Dis. 2003 Dec 15;188(12):1820-6
pubmed: 14673760
J Neuroimmunol. 2004 Feb;147(1-2):26-7
pubmed: 14741422
J Urban Health. 2005 Mar;82(1 Suppl 1):i120-6
pubmed: 15738313
Psychosom Med. 2006 Jan-Feb;68(1):143-51
pubmed: 16449425
AIDS Behav. 2007 Mar;11(2):277-87
pubmed: 16775771
AIDS Behav. 2007 Mar;11(2):185-94
pubmed: 16897351
PLoS Med. 2006 Nov;3(11):e438
pubmed: 17121449
AIDS Behav. 2008 Jan;12(1):86-94
pubmed: 17577653
AIDS Behav. 2007 Sep;11(5 Suppl):S6-16
pubmed: 17577655
J Neuroimmune Pharmacol. 2006 Sep;1(3):280-95
pubmed: 18040805
AIDS. 2008 Jan 30;22(3):357-65
pubmed: 18195562
Psychosom Med. 2008 Jun;70(5):539-45
pubmed: 18519880
AIDS. 2008 Jul 11;22(11):1355-63
pubmed: 18580615
Health Psychol. 2008 Jul;27(4):455-62
pubmed: 18643003
Curr HIV/AIDS Rep. 2009 Nov;6(4):177-86
pubmed: 19849960
Curr HIV/AIDS Rep. 2010 May;7(2):99-106
pubmed: 20425564
AIDS Res Hum Retroviruses. 2010 May;26(5):511-8
pubmed: 20455765
Curr HIV/AIDS Rep. 2010 Nov;7(4):226-33
pubmed: 20814765
Life Sci. 2011 May 23;88(21-22):940-7
pubmed: 20934437
J Acquir Immune Defic Syndr. 2011 Feb 1;56(2):146-50
pubmed: 21116186
Clin Infect Dis. 2011 Mar 15;52(6):793-800
pubmed: 21367734
PLoS One. 2011 Apr 25;6(4):e18462
pubmed: 21541016
N Engl J Med. 2011 Aug 11;365(6):493-505
pubmed: 21767103
J Acquir Immune Defic Syndr. 2011 Oct 1;58(2):181-7
pubmed: 21857529
Curr HIV/AIDS Rep. 2011 Dec;8(4):223-34
pubmed: 21858414
AIDS Behav. 2013 Jan;17(1):142-7
pubmed: 22246513
Curr Opin Psychiatry. 2012 May;25(3):165-71
pubmed: 22449770
AIDS Care. 2013;25(1):109-17
pubmed: 22670566
AIDS Behav. 2013 Jan;17(1):307-18
pubmed: 23108721
Addict Behav. 2013 Mar;38(3):1715-8
pubmed: 23254224
J Acquir Immune Defic Syndr. 2013 Jul;63 Suppl 2:S174-8
pubmed: 23764632
AIDS Behav. 2015 Apr;19(4):575-83
pubmed: 25331268
AIDS Behav. 2016 Apr;20(4):699-709
pubmed: 26246068
Curr HIV/AIDS Rep. 2015 Dec;12(4):421-36
pubmed: 26412084
J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):299-306
pubmed: 27258233
AIDS Behav. 2017 Jul;21(7):1825-1835
pubmed: 27392417
JAMA. 2016 Jul 12;316(2):191-210
pubmed: 27404187
Rev Saude Publica. 2016 Aug 22;50:54
pubmed: 27556968
J Int AIDS Soc. 2016 Sep 28;19(1):21096
pubmed: 27687145
Int J Drug Policy. 2017 Apr;42:63-70
pubmed: 28336000
AIDS Behav. 2017 Aug;21(8):2270-2282
pubmed: 28669024
J Infect Dis. 1993 Nov;168(5):1157-64
pubmed: 8228349
Arch Intern Med. 1998 Sep 14;158(16):1789-95
pubmed: 9738608

Auteurs

Kiyomi Tsuyuki (K)

Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0507, La Jolla, San Diego, CA, 92093-0507, USA. ktsuyuki@gmail.com.
ORCID: 0000-0002-9141-1395

Steven J Shoptaw (SJ)

David Geffen School of Medicine, Department of Family Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

Yusuf Ransome (Y)

Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Gordon Chau (G)

Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Carlos E Rodriguez-Diaz (CE)

University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

Ruth K Friedman (RK)

Instituto de Pesquisa Clinica Evandro Chagas, Rio de Janeiro, Brazil.

Kriengkrai Srithanaviboonchai (K)

Faculty of Medicine, Chiang Mai University, Muang District, Chiang Mai, Thailand.
Research Institute for Health Sciences, Chiang Mai University, Muang District, Chiang Mai, Thailand.

Sue Li (S)

Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Matthew J Mimiaga (MJ)

Center for Health Equity Research, Brown University, Providence, RI, USA.

Kenneth H Mayer (KH)

The Fenway Institute, Fenway Health, Boston, MA, USA.

Steven A Safren (SA)

Department of Psychology, University of Miami, Coral Gables, FL, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Agents antiVIH › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Régions géographiques › Amériques › Amérique du Sud › Brésil › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Comportement et mécanismes comportementaux › Émotions › Dépression › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Personnes › Usagers de drogues › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Sexualité › Hétérosexualité › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Sexualité › Homosexualité › Homosexualité masculine › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Attitude envers la santé › Adhésion et observance thérapeutiques › Acceptation des soins par les patients › Observance par le patient › Adhésion au traitement médicamenteux › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Troubles mentaux › Troubles liés à une substance › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Régions géographiques › Asie › Asie du Sud-Est › Thaïlande › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Jeune adulte › The Longitudinal Effects of Non-injection...
Recherchemedicale.com › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › Zambie › The Longitudinal Effects of Non-injection...