Autofluorescence lifetime augmented reality as a means for real-time robotic surgery guidance in human patients.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 02 2019
04 02 2019
Historique:
received:
30
11
2017
accepted:
27
11
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
20
8
2020
Statut:
epublish
Résumé
Due to loss of tactile feedback the assessment of tumor margins during robotic surgery is based only on visual inspection, which is neither significantly sensitive nor specific. Here we demonstrate time-resolved fluorescence spectroscopy (TRFS) as a novel technique to complement the visual inspection of oral cancers during transoral robotic surgery (TORS) in real-time and without the need for exogenous contrast agents. TRFS enables identification of cancerous tissue by its distinct autofluorescence signature that is associated with the alteration of tissue structure and biochemical profile. A prototype TRFS instrument was integrated synergistically with the da Vinci Surgical robot and the combined system was validated in swine and human patients. Label-free and real-time assessment and visualization of tissue biochemical features during robotic surgery procedure, as demonstrated here, not only has the potential to improve the intraoperative decision making during TORS but also other robotic procedures without modification of conventional clinical protocols.
Identifiants
pubmed: 30718542
doi: 10.1038/s41598-018-37237-8
pii: 10.1038/s41598-018-37237-8
pmc: PMC6362025
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1187Subventions
Organisme : NCI NIH HHS
ID : R01 CA187427
Pays : United States
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