No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study.

Adenocarcinoma / blood Barrett Esophagus / blood Biomarkers, Tumor / blood DNA, Neoplasm / genetics Esophageal Neoplasms / blood Europe / epidemiology Female Humans Male Mendelian Randomization Analysis / methods Morbidity North America / epidemiology Polymorphism, Single Nucleotide Risk Assessment Risk Factors Vitamin D / blood
BEACON Chemoprevention Esophageal Cancer Etiology Risk Factors

Journal

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN: 1542-7714
Titre abrégé: Clin Gastroenterol Hepatol
Pays: United States
ID NLM: 101160775

Informations de publication

Date de publication:
10 2019
Historique:
received: 24 10 2018
revised: 23 01 2019
accepted: 24 01 2019
pubmed: 5 2 2019
medline: 15 12 2020
entrez: 5 2 2019
Statut: ppublish

Résumé

Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC. Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18). In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

Sections du résumé

BACKGROUND & AIMS
Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).
METHODS
We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC.
RESULTS
Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18).
CONCLUSIONS
In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

Identifiants

DOI: 10.1016/j.cgh.2019.01.041 PMID: 30716477 PMC: PMC6675666
pubmed: 30716477
pii: S1542-3565(19)30088-6
doi: 10.1016/j.cgh.2019.01.041
pmc: PMC6675666
mid: NIHMS1520503
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
DNA, Neoplasm 0
Vitamin D 1406-16-2

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2227-2235.e1

Subventions

Organisme : NCI NIH HHS
ID : K05 CA124911
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA091955
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA136725
Pays : United States
Organisme : Cancer Research UK
ID : 10119
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 10124
Pays : United Kingdom

Informations de copyright

Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

Références

Int J Epidemiol. 2000 Aug;29(4):722-9
pubmed: 10922351
Am Heart J. 2002 Aug;144(2):212-8
pubmed: 12177636
Int J Epidemiol. 2003 Feb;32(1):1-22
pubmed: 12689998
Ann Epidemiol. 2007 Jul;17(7):511-3
pubmed: 17466535
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
PLoS Med. 2008 Aug 26;5(8):e177
pubmed: 18752343
Nat Rev Cancer. 2010 Feb;10(2):87-101
pubmed: 20094044
Am J Epidemiol. 2010 Jul 1;172(1):94-106
pubmed: 20562192
J Natl Cancer Inst. 2010 Sep 8;102(17):1344-53
pubmed: 20716718
Br J Nutr. 2011 Sep;106(5):732-41
pubmed: 21736847
Gastroenterology. 2012 Apr;142(4):744-53
pubmed: 22245667
Ann Oncol. 2012 Dec;23(12):3155-62
pubmed: 22847812
Am J Gastroenterol. 2012 Dec;107(12):1803-13
pubmed: 23032986
Am J Gastroenterol. 2013 Jun;108(6):915-22
pubmed: 23567358
Am J Epidemiol. 2013 Oct 1;178(7):1177-84
pubmed: 23863760
Genet Epidemiol. 2013 Nov;37(7):658-65
pubmed: 24114802
Nat Genet. 2013 Dec;45(12):1487-93
pubmed: 24121790
PLoS One. 2014 Jul 30;9(7):e103508
pubmed: 25075959
J Natl Cancer Inst. 2014 Sep 30;106(11):null
pubmed: 25269698
BMJ. 2014 Nov 18;349:g6330
pubmed: 25406188
Gastroenterology. 2015 Feb;148(2):367-78
pubmed: 25447851
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Dig Dis Sci. 2016 Jan;61(1):247-54
pubmed: 26233550
Stat Methods Med Res. 2017 Oct;26(5):2333-2355
pubmed: 26282889
Cancer Epidemiol. 2016 Apr;41:88-95
pubmed: 26851752
Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):877-86
pubmed: 27030602
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Bioinformatics. 2016 Oct 15;32(20):3207-3209
pubmed: 27318201
Lancet Oncol. 2016 Oct;17(10):1363-1373
pubmed: 27527254
Int J Epidemiol. 2016 Oct;45(5):1619-1630
pubmed: 27594614
Epidemiology. 2017 Jan;28(1):30-42
pubmed: 27749700
PLoS One. 2017 Sep 18;12(9):e0184928
pubmed: 28922414
BMJ. 2017 Oct 31;359:j4761
pubmed: 29089348
Nat Commun. 2018 Jan 17;9(1):260
pubmed: 29343764
Int J Cancer. 2018 Sep 1;143(5):1029-1036
pubmed: 29536507

Auteurs

Jing Dong (J)

Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Puya Gharahkhani (P)

Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Wong-Ho Chow (WH)

Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas.

Marilie D Gammon (MD)

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.

Geoffrey Liu (G)

Pharmacogenomic Epidemiology, Ontario Cancer Institute, Toronto, Ontario, Canada.

Carlos Caldas (C)

Cancer Research UK, Cambridge Institute, Cambridge, United Kingdom.

Anna H Wu (AH)

Department of Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.

Weimin Ye (W)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Lynn Onstad (L)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Lesley A Anderson (LA)

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.

Leslie Bernstein (L)

Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California.

Paul D Pharoah (PD)

Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Harvey A Risch (HA)

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

Douglas A Corley (DA)

Division of Research, Kaiser Permanente Northern California, Oakland, California; San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, California.

Rebecca C Fitzgerald (RC)

Medical Research Council Cancer Unit, Hutchison-Medical Research Council Research Centre, University of Cambridge, Cambridge, United Kingdom.

Prasad G Iyer (PG)

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Brian J Reid (BJ)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Jesper Lagergren (J)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom.

Nicholas J Shaheen (NJ)

Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.

Thomas L Vaughan (TL)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Stuart MacGregor (S)

Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Sharon Love (S)

Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Oxford, United Kingdom.

Claire Palles (C)

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.

Ian Tomlinson (I)

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.

Ines Gockel (I)

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.

Andrea May (A)

Department of Medicine II, Sana Klinikum, Offenbach, Germany.

Christian Gerges (C)

Department of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.

Mario Anders (M)

Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Gastroenterology and Interdisciplinary Endoscopy, Vivantes Wenckebach-Klinikum, Berlin, Germany.

Anne C Böhmer (AC)

Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

Jessica Becker (J)

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany; Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Nicole Kreuser (N)

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.

Rene Thieme (R)

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.

Tania Noder (T)

Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Marino Venerito (M)

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.

Lothar Veits (L)

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Thomas Schmidt (T)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Claudia Schmidt (C)

Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.

Jakob R Izbicki (JR)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.

Arnulf H Hölscher (AH)

Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.

Hauke Lang (H)

Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.

Dietmar Lorenz (D)

Department of General, Visceral and Thoracic Surgery, Klinikum Darmstadt, Darmstadt, Germany.

Brigitte Schumacher (B)

Department of Internal Medicine and Gastroenterology, Elisabeth Hospital, Essen, Germany.

Rupert Mayershofer (R)

Gastroenterologie am Burgweiher, Bonn, Germany.

Yogesh Vashist (Y)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany; Kantonsspital Aarau, Aarau, Switzerland.

Katja Ott (K)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany; Department of General, Visceral and Thorax Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany.

Michael Vieth (M)

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Josef Weismüller (J)

Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany.

Markus M Nöthen (MM)

Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

Susanne Moebus (S)

Centre of Urban Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany.

Michael Knapp (M)

Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany.

Wilbert H M Peters (WHM)

Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Horst Neuhaus (H)

Institute of Human Genetics, University of Bonn, Bonn, Germany.

Thomas Rösch (T)

Department of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.

Christian Ell (C)

Department of Medicine II, Sana Klinikum, Offenbach, Germany.

Janusz Jankowski (J)

Royal College of Surgeons in Ireland, Dublin, Ireland.

Johannes Schumacher (J)

Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

Rachel E Neale (RE)

Cancer Aetiology and Prevention, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

David C Whiteman (DC)

Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Aaron P Thrift (AP)

Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas. Electronic address: aaron.thrift@bcm.edu.

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Classifications MeSH

Recherchemedicale.com › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › No Association Between Vitamin D Status and...
Recherchemedicale.com › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'oesophage › Oesophage de Barrett › No Association Between Vitamin D Status and...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › No Association Between Vitamin D Status and...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › No Association Between Vitamin D Status and...
Recherchemedicale.com › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › No Association Between Vitamin D Status and...
Recherchemedicale.com › Régions géographiques › Europe › No Association Between Vitamin D Status and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › No Association Between Vitamin D Status and...
Recherchemedicale.com › Techniques d'investigation › Analyse de randomisation mendélienne › No Association Between Vitamin D Status and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › No Association Between Vitamin D Status and...
Recherchemedicale.com › Régions géographiques › Amériques › Amérique du Nord › No Association Between Vitamin D Status and...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › No Association Between Vitamin D Status and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › No Association Between Vitamin D Status and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › No Association Between Vitamin D Status and...
Recherchemedicale.com › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › No Association Between Vitamin D Status and...