Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study.
CD34-positive cell
consumptive reduction
elderly men
height
vascular maintenance
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
29 01 2019
29 01 2019
Historique:
received:
01
11
2018
accepted:
05
01
2019
pubmed:
30
1
2019
medline:
4
4
2020
entrez:
30
1
2019
Statut:
ppublish
Résumé
Recent studies have revealed an inverse association between height and cardiovascular disease and that endothelial progenitor cells (CD34-positive cells) contribute to vascular maintenance, which is associated with cardiovascular disease. However, evidence of the association between height and CD34-positive positive cells among elderly participants is limited. To assess this association, we conducted a cross-sectional study of 231 elderly Japanese men aged 65-69. Since enhanced production of circulating CD34-positive cells in response to endothelial injury might act have a strong confounding effect on the association between height and circulating CD34-positive cells, the median value for the levels of these cells (0.93 cells/μL) was used to stratify the participants. Multivariable linear regression analysis demonstrated that height was significantly positively associated with circulating CD34-positive cells for those participants with low levels of circulating CD34-positive cells (n=114) but not for those with higher levels (n=117), with a multi-adjusted standardized parameter estimate (β) of 0.27 (p=0.008) for low and 0.11 (0.275) for higher circulating CD34-positive cell levels. The positive association is limited to participants with relatively low circulating CD34-positive cell levels, whose productivity of these cells is not activated. Our findings indicate that height is an indicator of vascular maintenance capability in elderly Japanese men.
Identifiants
pubmed: 30695751
pii: 101768
doi: 10.18632/aging.101768
pmc: PMC6366994
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
663-672Références
Lancet. 2004 Jan 10;363(9403):157-63
pubmed: 14726171
Oncotarget. 2016 Jul 19;7(29):44919-44926
pubmed: 27374094
FASEB J. 2006 Dec;20(14):2559-61
pubmed: 17077283
Clin Orthop Relat Res. 2007 Dec;465:202-7
pubmed: 17891036
Ther Clin Risk Manag. 2015 Mar 06;11:381-91
pubmed: 25834453
Circulation. 2008 Jan 15;117(2):206-15
pubmed: 18086932
Int J Epidemiol. 2018 Feb 1;47(1):289-298
pubmed: 29025084
Geriatr Gerontol Int. 2017 Dec;17(12):2586-2592
pubmed: 28581690
Atherosclerosis. 2015 Nov;243(1):71-6
pubmed: 26363435
Aging (Albany NY). 2016 Oct 4;8(10):2407-2413
pubmed: 27705902
Blood. 1998 Jul 15;92(2):362-7
pubmed: 9657732
Environ Health Prev Med. 2018 May 3;23(1):16
pubmed: 29724162
Oncotarget. 2017 Dec 23;9(8):7749-7757
pubmed: 29487687
Environ Health Prev Med. 2017 Nov 21;22(1):77
pubmed: 29165175
Nat Med. 1999 Apr;5(4):434-8
pubmed: 10202935
Hematology Am Soc Hematol Educ Program. 2005;:528-32
pubmed: 16304431
J Hematother. 1996 Jun;5(3):213-26
pubmed: 8817388
Mech Ageing Dev. 2010 Nov-Dec;131(11-12):718-22
pubmed: 21035480
Science. 1997 Feb 14;275(5302):964-7
pubmed: 9020076
J Exp Med. 2006 Apr 17;203(4):1055-65
pubmed: 16606664
Clin Med Cardiol. 2009 May 27;3:53-60
pubmed: 20407620
Med Sci Monit. 2004 Apr;10(4):RA63-76
pubmed: 15039658
J Physiol Anthropol. 2017 Jun 15;36(1):26
pubmed: 28619079
Aging Male. 2015 Jun;18(2):100-5
pubmed: 25055346
Environ Health Prev Med. 2016 Sep;21(5):361-367
pubmed: 27164867
Sultan Qaboos Univ Med J. 2015 Aug;15(3):e344-50
pubmed: 26357554
Acta Paediatr. 2012 Mar;101(3):e115-21
pubmed: 22026536
Geriatr Gerontol Int. 2017 Oct;17(10):1729-1736
pubmed: 27562673
J Physiol Anthropol. 2016 Dec 6;35(1):29
pubmed: 27919279
Cell. 2000 Jul 21;102(2):199-209
pubmed: 10943840
Atherosclerosis. 2017 Apr;259:26-31
pubmed: 28282559
Eur J Epidemiol. 2011 Jan;26(1):13-21
pubmed: 20953671
Clin Hemorheol Microcirc. 1999;21(3-4):365-74
pubmed: 10711772
J Physiol Anthropol. 2013 Nov 01;32:19
pubmed: 24180493
J Stroke Cerebrovasc Dis. 2014 Apr;23(4):667-74
pubmed: 23871699
Proc (Bayl Univ Med Cent). 2011 Apr;24(2):115-8
pubmed: 21566758