Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
15
06
2018
accepted:
06
12
2018
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
19
1
2019
Statut:
epublish
Résumé
We demonstrate that the acrylamide group can be used to improve the drug-like properties of potential drug candidates. In the EGFR inhibitor development, both the solubility and membrane permeability properties of compounds
Identifiants
pubmed: 30655941
doi: 10.1021/acsmedchemlett.8b00270
pmc: PMC6331160
doi:
Types de publication
Journal Article
Langues
eng
Pagination
22-26Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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