Naltrexone and alcohol effects on craving for cigarettes in heavy drinking smokers.
Adult
Alcohol Drinking
/ psychology
Alcoholism
/ drug therapy
Breath Tests
Craving
/ drug effects
Double-Blind Method
Drug Interactions
Ethanol
/ pharmacology
Female
Humans
Male
Naltrexone
/ administration & dosage
Smokers
/ psychology
Smoking
/ psychology
Smoking Cessation
Tobacco Products
Young Adult
Journal
Experimental and clinical psychopharmacology
ISSN: 1936-2293
Titre abrégé: Exp Clin Psychopharmacol
Pays: United States
ID NLM: 9419066
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
11
1
2019
medline:
23
7
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
Naltrexone has been extensively studied for the treatment of alcohol use disorder. However, less is known about the effects of naltrexone on smoking outcomes in the context of alcohol use among East Asian individuals who have been suggested to differ in response to alcohol and to naltrexone. The present study is a secondary analysis that used a double-blind placebo-controlled design (n = 31) to examine the (a) effects of alcohol on basal craving for cigarettes, (b) effects of naltrexone on cigarette craving and alcohol craving during alcohol administration, and (c) relationship between craving for alcohol and cigarettes. Heavy drinking smokers of East Asian descent completed two counterbalanced intravenous alcohol administration sessions, one after taking naltrexone (50 mg) for five days and one after taking a placebo for five days. Self-reported subjective craving for cigarettes and for alcohol was recorded during each experimental session. Craving for cigarettes and alcohol increased significantly throughout the intravenous alcohol administration. A significant breath alcohol concentration (BrAC) × Medication interaction revealed that naltrexone blunted cigarette craving during alcohol administration, compared to placebo. Naltrexone significantly reduced craving for alcohol during alcohol administration in this group of heavy drinking smokers. Alcohol craving significantly predicted cigarette craving, however this effect did not vary across rising alcohol administration or by medication. These findings demonstrate that naltrexone reduces the urge to smoke and to drink during alcohol administration. Clinical studies are needed to further ascertain whether naltrexone may be of benefit to this distinct subgroup of heavy drinking smokers. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Identifiants
pubmed: 30628813
pii: 2019-01044-001
doi: 10.1037/pha0000252
pmc: PMC7227763
mid: NIHMS1048329
doi:
Substances chimiques
Ethanol
3K9958V90M
Naltrexone
5S6W795CQM
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
257-264Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR033176
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA025704
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007272
Pays : United States
Organisme : University of California, Los Angeles; Integrated Substance Abuse Program
Organisme : NIAAA NIH HHS
ID : R01 AA021744
Pays : United States
Organisme : University of California, Los Angeles Clinical and Translational Science Institute
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