A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population.
GRM7
Glutamate receptor
Multiple sclerosis
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
10
09
2018
revised:
29
12
2018
accepted:
02
01
2019
pubmed:
8
1
2019
medline:
14
6
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
Glutamate excitotoxicity has been previously associated with development of multiple sclerosis (MS). The metabotropic glutamate receptor 7 (GRM7) gene is a G protein-coupled receptor that suppresses the cyclic AMP cascade after activation by glutamate. Single nucleotide polymorphisms (SNPs) within this gene have been reported to be associated with neuropsychiatric disorders. In the present study, we assessed associations between two intronic variants of GRM7 (rs6782011 and rs779867) and risk of MS in an Iranian population. The rs779867 was associated with MS risk in recessive model (OR (95% CI) = 0.67 (0.48-0.94)), P-value = 0.02, adjusted P-value = 0.04). There was no significant difference in allele and genotype frequencies of rs6782011 between cases and controls. None of the estimated haplotype blocks of rs6782011 and rs779867 were associated with MS risk in the assessed population. The current study provides some evidence for participation of GRM7 in the pathogenesis of MS and warrants further studies in larger sample sizes.
Identifiants
pubmed: 30616226
pii: S2211-0348(19)30008-2
doi: 10.1016/j.msard.2019.01.012
pii:
doi:
Substances chimiques
Receptors, Metabotropic Glutamate
0
metabotropic glutamate receptor 7
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-192Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.