High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review.

Adrenal Cortex Hormones / therapeutic use Anti-Inflammatory Agents / therapeutic use Cytomegalovirus Infections / complications Humans Immunocompetence / drug effects Male Methylprednisolone / therapeutic use Middle Aged Myelitis, Transverse / drug therapy
Corticosteroids Cytomegalovirus Immunocompetent Methylprednisolone Myelitis

Journal

Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123

Informations de publication

Date de publication:
06 2019
Historique:
received: 01 11 2018
accepted: 18 12 2018
pubmed: 6 1 2019
medline: 23 9 2020
entrez: 6 1 2019
Statut: ppublish

Résumé

We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use of immunosuppressive therapy for this potentially infectious myelopathy, we systematically reviewed the literature to assess outcomes after administration of high-dose corticosteroids to this population. Despite severe disease at clinical nadir with inability to ambulate, immunocompetent patients with acute CMV-associated TM who received high-dose corticosteroids had good clinical outcomes 1 month to 1 year after presentation.

Identifiants

DOI: 10.1007/s13365-018-0717-2 PMID: 30610740
pubmed: 30610740
doi: 10.1007/s13365-018-0717-2
pii: 10.1007/s13365-018-0717-2
doi:

Substances chimiques

Adrenal Cortex Hormones 0
Anti-Inflammatory Agents 0
Methylprednisolone X4W7ZR7023

Types de publication

Case Reports Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

405-409

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Auteurs

A Budhram (A)

Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada. adrian.budhram@lhsc.on.ca.

Y Liu (Y)

Department of Medicine, Division of General Internal Medicine, Western University, London, Ontario, N6A 5A5, Canada.

M Krawczyk (M)

Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.

T L H Chan (TLH)

Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.

J G Burneo (JG)

Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.

S M Hosseini-Moghaddam (SM)

Department of Medicine, Division of Infectious Diseases, Western University, London, Ontario, N6A 5A5, Canada.

C Shoesmith (C)

Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.

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Classifications MeSH

Recherchemedicale.com › Hormones corticosurrénaliennes › High-dose corticosteroids for acute...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › High-dose corticosteroids for acute...
Recherchemedicale.com › Infection › Maladies virales › Infections à virus à ADN › Infections à Herpesviridae › Infections à cytomégalovirus › High-dose corticosteroids for acute...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High-dose corticosteroids for acute...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunocompétence › High-dose corticosteroids for acute...
Recherchemedicale.com › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnadiènes › Prégnadiènetriols › Prednisolone › Méthylprednisolone › High-dose corticosteroids for acute...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › High-dose corticosteroids for acute...
Recherchemedicale.com › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Myélite transverse › High-dose corticosteroids for acute...