A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice.
Animals
Behavior, Animal
Binding Sites
Eutheria
/ genetics
Excitatory Postsynaptic Potentials
Genetic Association Studies
Genetic Markers
Hippocampus
/ metabolism
Mice
Mice, Knockout
MicroRNAs
/ genetics
Multigene Family
Phenotype
Protein Interaction Mapping
Protein Interaction Maps
Pyramidal Cells
/ metabolism
RNA Interference
Receptors, Glutamate
/ metabolism
Social Behavior
Synaptic Transmission
autism
glutamate receptor
hippocampus
microRNA
sociability
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
16
05
2018
revised:
16
11
2018
accepted:
23
11
2018
pubmed:
16
12
2018
medline:
21
4
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Aberrant synaptic function is thought to underlie social deficits in neurodevelopmental disorders such as autism and schizophrenia. Although microRNAs have been shown to regulate synapse development and plasticity, their potential involvement in the control of social behaviour in mammals remains unexplored. Here, we show that deletion of the placental mammal-specific miR379-410 cluster in mice leads to hypersocial behaviour, which is accompanied by increased excitatory synaptic transmission, and exaggerated expression of ionotropic glutamate receptor complexes in the hippocampus. Bioinformatic analyses further allowed us to identify five "hub" microRNAs whose deletion accounts largely for the upregulation of excitatory synaptic genes observed, including Cnih2, Dlgap3, Prr7 and Src. Thus, the miR379-410 cluster acts a natural brake for sociability, and interfering with specific members of this cluster could represent a therapeutic strategy for the treatment of social deficits in neurodevelopmental disorders.
Identifiants
pubmed: 30552145
pii: embr.201846429
doi: 10.15252/embr.201846429
pmc: PMC6362351
pii:
doi:
Substances chimiques
Genetic Markers
0
MicroRNAs
0
Receptors, Glutamate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 The Authors.
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