Azadirachta indica inhibits key enzyme linked to type 2 diabetes in vitro, abates oxidative hepatic injury and enhances muscle glucose uptake ex vivo.
Animals
Azadirachta
Diabetes Mellitus, Experimental
/ drug therapy
Diabetes Mellitus, Type 2
/ drug therapy
Enzyme Inhibitors
/ isolation & purification
Glucose
/ metabolism
Hypoglycemic Agents
/ isolation & purification
Liver
/ drug effects
Male
Muscle, Skeletal
/ drug effects
Oxidative Stress
/ drug effects
Plant Bark
Plant Extracts
/ isolation & purification
Protein Structure, Secondary
Rats
Rats, Sprague-Dawley
Antidiabetic
Azadirachta indica
Glucose uptake
Oxidative stress
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
21
08
2018
revised:
24
10
2018
accepted:
30
10
2018
entrez:
16
12
2018
pubmed:
16
12
2018
medline:
2
4
2019
Statut:
ppublish
Résumé
The progression of secondary complications in type 2 diabetes (T2D) has been linked to oxidative stress caused by hyperglycemia. Therefore, the control of hyperglycemia is the main target in the treatment of diabetes. The present study investigated the scavenging and ameliorative potentials of different fractions of Azadirachta indica (A. indica) ethanol stem bark extract in Fe
Identifiants
pubmed: 30551526
pii: S0753-3322(18)35890-6
doi: 10.1016/j.biopha.2018.10.171
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Hypoglycemic Agents
0
Plant Extracts
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
734-743Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.