Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis.
(64)Cu
Antisense drugs
Liposomes
Liquid chromatography-tandem mass spectrometry
Pharmacokinetics
Positron emission tomography
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
28 01 2019
28 01 2019
Historique:
received:
01
09
2018
revised:
04
12
2018
accepted:
06
12
2018
pubmed:
12
12
2018
medline:
21
3
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for medical use. We previously developed wrapsome® (WS), an ~100 nm liposomal nanoparticle that can encapsulate siRNA, and reported that WS accumulates in tumors in vivo and inhibits their growth by an enhanced permeability and retention effect. In the present study, we evaluated the pharmacokinetics of nucleic acid-containing nanoparticles by combining dynamic positron emission tomography (PET) imaging and liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. An 18-mer phosphorothioate oligodeoxynucleotide (ODN), trabedersen, was used as a model drug and was encapsulated in WS. Dynamic PET imaging and time-activity curve analysis of WS-encapsulated
Identifiants
pubmed: 30529725
pii: S0168-3659(18)30701-6
doi: 10.1016/j.jconrel.2018.12.006
pii:
doi:
Substances chimiques
Liposomes
0
Oligonucleotides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-194Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.