Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort.

Cohort Studies Female Frontotemporal Dementia / diagnostic imaging Humans Magnetic Resonance Imaging / methods Male Middle Aged Neuroimaging / methods Prodromal Symptoms Spatio-Temporal Analysis Thalamus / diagnostic imaging

Clustering Computational anatomy Parallel transport Shape analysis Spatiotemporal geodesic regression Thalamus

Journal

NeuroImage

ISSN: 1095-9572

Titre abrégé: Neuroimage

Pays: United States

ID NLM: 9215515

Informations de publication

Date de publication:
03 2019

Historique:

received: 05 08 2018

revised: 15 11 2018

accepted: 30 11 2018

pubmed: 12 12 2018

medline: 22 1 2020

entrez: 12 12 2018

Statut: ppublish

Résumé

Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease.

Identifiants

DOI: 10.1016/j.neuroimage.2018.11.063 PMID: 30529631 PMC: PMC6414401

pubmed: 30529631

pii: S1053-8119(18)32144-X

doi: 10.1016/j.neuroimage.2018.11.063

pmc: PMC6414401

pii:

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng