Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.
Adenoviridae
/ genetics
Animals
Aorta
/ drug effects
Arginase
/ antagonists & inhibitors
Cattle
Cells, Cultured
Endothelial Cells
/ drug effects
Endothelium, Vascular
/ physiology
Glucose
/ pharmacology
Hyperglycemia
/ complications
Male
Mice, Inbred C57BL
Mice, Knockout
Protein Kinase Inhibitors
/ pharmacology
Protein Kinases
/ physiology
Vasodilation
Arginase
Diabetes
Endothelial dysfunction
Rho kinase
Stress kinase
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
received:
23
05
2018
revised:
15
11
2018
accepted:
20
11
2018
pubmed:
7
12
2018
medline:
2
5
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Diabetes-induced vascular endothelial dysfunction has been reported to involve hyperglycemia-induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38 MAPK pathways in this process. Studies were performed with aortas isolated from wild type or hemizygous arginase 1 knockout (Arg1
Identifiants
pubmed: 30502342
pii: S0014-2999(18)30682-4
doi: 10.1016/j.ejphar.2018.11.027
pmc: PMC6326844
mid: NIHMS1516388
pii:
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Protein Kinases
EC 2.7.-
Arginase
EC 3.5.3.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-37Subventions
Organisme : NEI NIH HHS
ID : R01 EY011766
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070215
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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