Cancer specific survival in patients with sickle cell disease.
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Anemia, Sickle Cell
/ epidemiology
California
/ epidemiology
Comorbidity
Disease Susceptibility
Ethnicity
/ statistics & numerical data
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Neoplasms
/ epidemiology
Proportional Hazards Models
Risk
Sex Distribution
Young Adult
Sickle cell disease
cancer
epidemiology
survival
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
15
08
2018
accepted:
12
10
2018
pubmed:
24
11
2018
medline:
26
2
2020
entrez:
24
11
2018
Statut:
ppublish
Résumé
Sickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state-wide hospitalisation data, were linked to the California Cancer Registry (1988-2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3-fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer-specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.
Identifiants
pubmed: 30467842
doi: 10.1111/bjh.15687
pmc: PMC8966490
mid: NIHMS1787249
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-132Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL129033
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000035C
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U58 DP003862
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000034C
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001860
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000140C
Pays : United States
Informations de copyright
© 2018 British Society for Haematology and John Wiley & Sons Ltd.
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