Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.
Androgens
Randomized controlled trial
SHBG
Testosterone
Vitamin D
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
07
08
2018
accepted:
04
11
2018
pubmed:
22
11
2018
medline:
28
4
2020
entrez:
22
11
2018
Statut:
ppublish
Résumé
It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition. Ninety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables. Vitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels.
Identifiants
pubmed: 30460609
doi: 10.1007/s00394-018-1858-z
pii: 10.1007/s00394-018-1858-z
pmc: PMC6842386
doi:
Substances chimiques
Androgens
0
Vitamins
0
Vitamin D
1406-16-2
Testosterone
3XMK78S47O
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
3135-3146Subventions
Organisme : ÖNB Jubiläumsfonds
ID : 14846
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