Pharmacokinetics of difloxacin in Japanese quails (Coturnix japonica) after single intravenous and oral administration.

Administration, Intravenous Administration, Oral Animals Area Under Curve Biological Availability Ciprofloxacin / administration & dosage Coturnix / blood Fluoroquinolones / administration & dosage Half-Life Injections, Intramuscular Injections, Intravenous
Difloxacin Pharmacokinetics Quails

Journal

Research in veterinary science
ISSN: 1532-2661
Titre abrégé: Res Vet Sci
Pays: England
ID NLM: 0401300

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 11 05 2018
revised: 29 10 2018
accepted: 11 11 2018
pubmed: 20 11 2018
medline: 12 3 2019
entrez: 20 11 2018
Statut: ppublish

Résumé

Pharmacokinetics of difloxacin (DF), a fluoroquinolone antibiotic, were investigated in Japanese quails (Coturnix japonica) after a single intravenous (IV) and oral (PO) administration of 10 mg/kg bodyweight. Plasma concentration profiles of DF were analyzed by a compartmental pharmacokinetic method. Following IV injection, the plasma concentration vs time profile was best described by a two-compartment open model. Elimination half-life (t

Identifiants

DOI: 10.1016/j.rvsc.2018.11.012 PMID: 30453178
pubmed: 30453178
pii: S0034-5288(18)30437-5
doi: 10.1016/j.rvsc.2018.11.012
pii:
doi:

Substances chimiques

Fluoroquinolones 0
Ciprofloxacin 5E8K9I0O4U
difloxacin 5Z7OO9FNFD

Types de publication

Clinical Trial, Veterinary Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

36-39

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

M Aboubakr (M)

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Elqaliobiya, Egypt.

M Elbadawy (M)

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Elqaliobiya, Egypt. Electronic address: mohamed.elbadawy@fvtm.bu.edu.eg.

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Classifications MeSH

Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie intraveineuse › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Eucaryotes › Animaux › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Ciprofloxacine › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Galliformes › Caille › Coturnix › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Phénomènes physiques › Temps › Période › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections musculaires › Pharmacokinetics of difloxacin in Japanese...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections veineuses › Pharmacokinetics of difloxacin in Japanese...