Early Parenting Intervention and Adverse Family Environments Affect Neural Function in Middle Childhood.
Brain maturation
Childhood maltreatment
Early adversity
Early intervention
Parenting
Resting EEG
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
13
02
2018
revised:
17
09
2018
accepted:
18
09
2018
pubmed:
19
11
2018
medline:
1
2
2020
entrez:
19
11
2018
Statut:
ppublish
Résumé
Growing work points to the negative impact of early adverse experiences on the developing brain. An outstanding question concerns the extent to which early intervention can normalize trajectories of brain development in at-risk children. We tested this within the context of a randomized clinical trial of an early parenting program, the Attachment and Biobehavioral Catch-up (ABC), delivered to parents and infants monitored for maltreatment by Child Protective Services. Families participated in the randomized clinical trial when children were 2.5 years of age or younger. Parenting and home adversity was measured at baseline. Children were followed longitudinally, and resting brain activity was measured electrophysiologically (n = 106) when children reached 8 years of age. Spectral power was quantified and compared across children assigned to the experimental intervention (ABC), a control intervention, and a low-risk comparison group (n = 76) recruited at the follow-up assessment. Higher early home adversity was associated with electrophysiological profiles indicative of cortical delays/immaturity in middle childhood, based on relatively greater power in lower frequency bands (theta, 4-6 Hz, and low alpha, 6-9 Hz) and lower power in a higher frequency band (high alpha, 9-12 Hz). Children assigned to ABC showed relatively greater high-frequency power (beta, 12-20 Hz) than children assigned to the control intervention. Beta power in the ABC did not differ from that of the low-risk comparison group. Maltreatment risk and home adversity can affect indicators of middle childhood brain maturation. Early parenting programs can support more normative patterns of neural function during middle childhood.
Sections du résumé
BACKGROUND
Growing work points to the negative impact of early adverse experiences on the developing brain. An outstanding question concerns the extent to which early intervention can normalize trajectories of brain development in at-risk children. We tested this within the context of a randomized clinical trial of an early parenting program, the Attachment and Biobehavioral Catch-up (ABC), delivered to parents and infants monitored for maltreatment by Child Protective Services.
METHODS
Families participated in the randomized clinical trial when children were 2.5 years of age or younger. Parenting and home adversity was measured at baseline. Children were followed longitudinally, and resting brain activity was measured electrophysiologically (n = 106) when children reached 8 years of age. Spectral power was quantified and compared across children assigned to the experimental intervention (ABC), a control intervention, and a low-risk comparison group (n = 76) recruited at the follow-up assessment.
RESULTS
Higher early home adversity was associated with electrophysiological profiles indicative of cortical delays/immaturity in middle childhood, based on relatively greater power in lower frequency bands (theta, 4-6 Hz, and low alpha, 6-9 Hz) and lower power in a higher frequency band (high alpha, 9-12 Hz). Children assigned to ABC showed relatively greater high-frequency power (beta, 12-20 Hz) than children assigned to the control intervention. Beta power in the ABC did not differ from that of the low-risk comparison group.
CONCLUSIONS
Maltreatment risk and home adversity can affect indicators of middle childhood brain maturation. Early parenting programs can support more normative patterns of neural function during middle childhood.
Identifiants
pubmed: 30447912
pii: S0006-3223(18)31891-2
doi: 10.1016/j.biopsych.2018.09.020
pmc: PMC6373871
mid: NIHMS1512718
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-335Subventions
Organisme : NIMH NIH HHS
ID : R01 MH052135
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074374
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH084135
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Références
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18
pubmed: 12732219
J Sch Psychol. 2017 Oct;64:109-127
pubmed: 28735604
Child Adolesc Psychiatr Clin N Am. 2005 Jan;14(1):21-53, v-vi
pubmed: 15564051
Dev Cogn Neurosci. 2016 Feb;17:68-75
pubmed: 26724564
Science. 1985 May 10;228(4700):750-2
pubmed: 3992243
Child Dev. 1987 Jun;58(3):539-59
pubmed: 3038480
Dev Psychopathol. 2015 Aug;27(3):829-41
pubmed: 25156798
Biol Psychiatry. 2013 Dec 1;74(11):845-52
pubmed: 23954109
Dev Sci. 2011 Mar;14(2):190-204
pubmed: 21399712
Dev Neuropsychol. 2007;31(1):21-38
pubmed: 17305436
Int J Neurosci. 1986 Aug;30(1-2):81-5
pubmed: 3744715
Cogn Affect Behav Neurosci. 2010 Mar;10(1):34-49
pubmed: 20233954
Front Hum Neurosci. 2012 Mar 19;6:52
pubmed: 22457645
Electroencephalogr Clin Neurophysiol. 1996 Apr;98(4):281-93
pubmed: 8641150
Front Neurosci. 2018 Aug 07;12:513
pubmed: 30131667
Electroencephalogr Clin Neurophysiol. 1997 Jun;102(6):512-6
pubmed: 9216484
Electroencephalogr Clin Neurophysiol. 1988 Feb;69(2):91-9
pubmed: 2446839
Neuroreport. 2000 Aug 21;11(12):2663-8
pubmed: 10976940
PLoS One. 2010 Jul 01;5(7):e11415
pubmed: 20617175
Front Neurosci. 2018 Feb 27;12:97
pubmed: 29535597
Dev Psychopathol. 2003 Fall;15(4):885-907
pubmed: 14984131
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12927-32
pubmed: 22826224
Child Dev. 1984 Oct;55(5):1913-25
pubmed: 6510061
Psychophysiology. 1993 Nov;30(6):547-58
pubmed: 8248447
Front Psychiatry. 2011 Jul 28;2:48
pubmed: 21847382
Child Dev. 2012 Mar-Apr;83(2):623-36
pubmed: 22239483
Biol Psychol. 1997 Jan 31;44(3):187-209
pubmed: 9043653
Cereb Cortex. 2010 Mar;20(3):561-9
pubmed: 19546156
Child Abuse Negl. 2014 Sep;38(9):1459-67
pubmed: 24814751
Psychoneuroendocrinology. 2017 Jan;75:152-163
pubmed: 27829190
Clin Neurophysiol. 2011 Jul;122(7):1327-32
pubmed: 21310652
J Cogn Neurosci. 2015 Dec;27(12):2512-28
pubmed: 26351990
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15638-43
pubmed: 24019460
Biol Psychiatry. 2014 Oct 15;76(8):629-38
pubmed: 24090797
Clin Neurophysiol. 2001 May;112(5):806-14
pubmed: 11336896
Dev Sci. 2010 Jan 1;13(1):46-61
pubmed: 20121862
Science. 1980 Dec 12;210(4475):1255-8
pubmed: 7434026
Clin Neurophysiol. 2003 Oct;114(10):1918-25
pubmed: 14499754
Neuropsychologia. 2014 May;58:33-51
pubmed: 24709570
Clin Neurophysiol. 2003 Feb;114(2):171-83
pubmed: 12559224
Hum Brain Mapp. 2018 Mar;39(3):1283-1290
pubmed: 29250891
Electroencephalogr Clin Neurophysiol. 1984 Jan;57(1):1-12
pubmed: 6198138
Prev Sci. 2009 Jun;10(2):129-40
pubmed: 19030992
JAMA Pediatr. 2015 Mar;169(3):211-9
pubmed: 25622303
Psychiatry Res. 1998 Oct 19;81(1):19-29
pubmed: 9829647
Infant Ment Health J. 2013 Mar 1;34(2):95-103
pubmed: 23997377
Biol Psychiatry. 2010 Aug 15;68(4):329-36
pubmed: 20497899
Behav Brain Sci. 2000 Jun;23(3):371-98; discussion 399-437
pubmed: 11301576
Pediatrics. 2006 Jun;117(6):2093-100
pubmed: 16740852
Curr Opin Neurobiol. 2010 Apr;20(2):156-65
pubmed: 20359884
Clin Neurophysiol. 2002 Aug;113(8):1199-208
pubmed: 12139998
Neuroimage. 2001 Dec;14(6):1290-301
pubmed: 11707085
Neuropadiatrie. 1971 Feb;2(3):247-304
pubmed: 5171359
Child Maltreat. 2017 May;22(2):174-179
pubmed: 28152611