In vivo visualization of age-related differences in the locus coeruleus.
Aging
Locus coeruleus
Magnetic resonance imaging
Neuromelanin
Noradrenergic system
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
26
03
2018
revised:
06
10
2018
accepted:
11
10
2018
pubmed:
18
11
2018
medline:
27
11
2019
entrez:
18
11
2018
Statut:
ppublish
Résumé
The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, may play an important role in neuropsychiatric disorders including Parkinson's disease and Alzheimer's disease. The pattern of age-related change of the LC across the life span is unclear. We obtained normalized, mean LC signal intensity values, that is, contrast ratios (CRs), from magnetization transfer-weighted images to investigate the relationship between LC CR and age in cognitively normal healthy adults (N = 605, age range 18-88 years). Study participants were part of the Cambridge Centre for Ageing and Neuroscience-an open-access, population-based data set. We found a quadratic relationship between LC CR and age, the peak occurring around 60 years, with no differences between males and females. Subregional analyses revealed that age-related decline in LC CR was confined to the rostral portion of the LC. Older adults showed greater variance in overall LC CR than younger adults, and the functional and clinical implications of these observed age-related differences require further investigation. Visualization of the LC in this study may inform how future scanning parameters can be optimized, and provides insight into how LC integrity changes across the life span.
Identifiants
pubmed: 30447418
pii: S0197-4580(18)30378-6
doi: 10.1016/j.neurobiolaging.2018.10.014
pmc: PMC6338679
pii:
doi:
Substances chimiques
Melanins
0
neuromelanin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-111Subventions
Organisme : Medical Research Council
ID : MR/P012698/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/9
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1401/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/8
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H008217/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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