Frequency-specific noninvasive modulation of memory retrieval and its relationship with hippocampal network connectivity.
Adolescent
Adult
Beta Rhythm
/ physiology
Brain Mapping
Female
Functional Neuroimaging
Healthy Volunteers
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic
Mental Recall
/ physiology
Nerve Net
/ diagnostic imaging
Neural Pathways
/ diagnostic imaging
Parietal Lobe
/ diagnostic imaging
Theta Rhythm
/ physiology
Transcranial Magnetic Stimulation
Young Adult
TMS
hippocampus
neuromodulation
recognition
theta-burst stimulation
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
01
10
2018
accepted:
11
11
2018
pubmed:
18
11
2018
medline:
2
6
2020
entrez:
18
11
2018
Statut:
ppublish
Résumé
Episodic memory is thought to rely on interactions of the hippocampus with other regions of the distributed hippocampal-cortical network (HCN) via interregional activity synchrony in the theta frequency band. We sought to causally test this hypothesis using network-targeted transcranial magnetic stimulation. Healthy human participants completed four experimental sessions, each involving a different stimulation pattern delivered to the same individualized parietal cortex location of the HCN for all sessions. There were three active stimulation conditions, including continuous theta-burst stimulation, intermittent theta-burst stimulation, and beta-frequency (20-Hz) repetitive stimulation, and one sham condition. Resting-state fMRI and episodic memory testing were used to assess the impact of stimulation on hippocampal fMRI connectivity related to retrieval success. We hypothesized that theta-burst stimulation conditions would most strongly influence hippocampal-HCN fMRI connectivity and retrieval, given the hypothesized relevance of theta-band activity for HCN memory function. Continuous theta-burst stimulation improved item retrieval success relative to sham and relative to beta-frequency stimulation, whereas intermittent theta-burst stimulation led to numerical but nonsignificant item retrieval improvement. Mean hippocampal fMRI connectivity did not vary for any stimulation conditions, whereas individual differences in retrieval improvements due to continuous theta-burst stimulation were associated with corresponding increases in fMRI connectivity between the hippocampus and other HCN locations. No such memory-related connectivity effects were identified for the other stimulation conditions, indicating that only continuous theta-burst stimulation affected memory-related hippocampal-HCN connectivity. Furthermore, these effects were specific to the targeted HCN, with no significant memory-related fMRI connectivity effects for two distinct control brain networks. These findings support a causal role for fMRI connectivity of the hippocampus with the HCN in episodic memory retrieval and indicate that contributions of this network to retrieval are particularly sensitive to continuous theta-burst noninvasive stimulation.
Identifiants
pubmed: 30447076
doi: 10.1002/hipo.23054
pmc: PMC6525080
mid: NIHMS1002880
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-609Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111790
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106512
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS047987
Pays : United States
Organisme : NINDS NIH HHS
ID : T32-NS047987
Pays : United States
Organisme : NIMH NIH HHS
ID : R01-MH106512 R01-MH111790
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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