Temporal stability of urinary cadmium in samples collected several years apart in a population of older persons.


Journal

International journal of hygiene and environmental health
ISSN: 1618-131X
Titre abrégé: Int J Hyg Environ Health
Pays: Germany
ID NLM: 100898843

Informations de publication

Date de publication:
03 2019
Historique:
received: 09 07 2018
revised: 10 10 2018
accepted: 30 10 2018
pubmed: 8 11 2018
medline: 14 1 2020
entrez: 8 11 2018
Statut: ppublish

Résumé

There is growing evidence that urine cadmium is a temporally stable biomarker indicative of long-term cadmium exposure; however questions remain with regard to generalizability to older persons, the impact of changes in smoking behavior, and the degree of temporal stability when repeat sample collection spans years instead of weeks or months. Using archived samples from cohorts of older men (Osteoporotic Fractures in Men (MrOS-US)) and women (Study of Osteoporotic Fractures (SOF)) (mean age = 80 at study visit 2), we analyzed two morning urine samples each from 39 men and 18 women with a diverse self-reported smoking history. For MrOS, samples were collected approximately 6 years apart, and 4 years apart for SOF. Intra-class correlations were computed to assess temporal stability, and adjusted for age and body mass index. The median creatinine-adjusted urinary cadmium levels (0.39 μg/g for men, 0.89 μg/g for women) were similar to levels expected for these age/sex groups in the US according to the National Health and Nutrition Examination Survey. The overall intra-class correlation was high (ICC = 0.85; 95% CI: 0.76-0.91) and similar between cohorts (MrOS: ICC = 0.74; 95% CI: 0.58-0.86; SOF: ICC = 0.81; 95% CI: 0.59-0.93), but slightly lower among those who stopped smoking between visits of sample collection (ICC = 0.64; 95% CI: 0.31-0.87) or among former smokers who quit prior to the first sample collection (ICC = 0.68; 95% CI: 0.25-0.93). We report good-to-excellent reproducibility of urine cadmium using morning urine samples collected 4-6 years apart from older men and women, but slightly lower correlations among those with a history of smoking. Single measures of urine cadmium are a reliable biomarker in older men and women.

Identifiants

pubmed: 30401599
pii: S1438-4639(18)30580-7
doi: 10.1016/j.ijheh.2018.10.005
pmc: PMC6408983
mid: NIHMS1511627
pii:
doi:

Substances chimiques

Biomarkers 0
Environmental Pollutants 0
Cadmium 00BH33GNGH

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

230-234

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL070848
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071194
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070847
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000128
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR035583
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002369
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG026720
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR035584
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070842
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042124
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042145
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027576
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG005407
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042168
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070841
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026614
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042140
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070838
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070839
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR035582
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG027810
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG005394
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070837
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042143
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042139
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027574
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR066160
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier GmbH. All rights reserved.

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Auteurs

Jaymie R Meliker (JR)

Program in Public Health, Department of Family, Population, & Preventive Medicine, USA; Stony Brook University School of Medicine, USA. Electronic address: Jaymie.meliker@stonybrook.edu.

Caterina Vacchi-Suzzi (C)

Stony Brook University School of Medicine, USA; Cancer Center, USA.

James Harrington (J)

Trace Inorganics Laboratory, RTI International, USA.

Keith Levine (K)

Trace Inorganics Laboratory, RTI International, USA.

Li-Yung Lui (LY)

California Pacific Medical Center, USA.

Douglas C Bauer (DC)

University of California San Francisco School of Medicine, USA.

Eric Orwoll (E)

Oregon Health & Science University School of Medicine, USA.

Deborah M Kado (DM)

Department of Family Medicine & Public Health and Medicine, University of California San Diego, USA.

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Classifications MeSH