Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study.
MRI
endophenotype
hippocampal sclerosis
mesial temporal lobe epilepsy
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
07
06
2018
revised:
11
09
2018
accepted:
11
09
2018
pubmed:
17
10
2018
medline:
10
4
2020
entrez:
17
10
2018
Statut:
ppublish
Résumé
We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first-degree asymptomatic relatives of patients with mTLE+HS. Using T1-weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole-brain MRI in 19 patients with mTLE+HS, 14 first-degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants. Structural alterations in patients and relatives compared to controls were assessed using automated hippocampal volumetry and cortical surface-based morphometry. We replicated previously reported cortical surface area contractions in the ipsilateral anterior temporal lobe in both patients and relatives compared to healthy controls, with asymptomatic relatives showing similar but less extensive changes than patients. These findings suggest morphologic abnormality in asymptomatic relatives of mTLE+HS patients, suggesting an inherited brain structure endophenotype.
Identifiants
pubmed: 30324623
doi: 10.1111/epi.14575
pmc: PMC6334277
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1-e5Subventions
Organisme : Medical Research Council
ID : MR/K013998/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : National Institute for Health Research Biomedical Research Centre
Pays : International
Organisme : Engineering and Physical Sciences Research Council
ID : EP/N014391/1
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.
Références
Genes Brain Behav. 2014 Mar;13(3):333-40
pubmed: 24286483
J Neuroimaging. 2013 Jan;23(1):64-70
pubmed: 22928655
Neurology. 2013 Jul 9;81(2):144-9
pubmed: 23749796
PLoS One. 2013 Apr 23;8(4):e61880
pubmed: 23626743
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Neuroimage. 2010 Dec;53(4):1244-55
pubmed: 20600995
Quant Imaging Med Surg. 2015 Apr;5(2):204-24
pubmed: 25853080
Clin Neurophysiol. 2010 Aug;121(8):1153-75
pubmed: 20185365
Cereb Cortex. 2016 Mar;26(3):1234-41
pubmed: 25576532
Eur J Hum Genet. 2009 Sep;17(9):1171-81
pubmed: 19172991
Nat Commun. 2015 Jan 23;6:6031
pubmed: 25615886
Front Hum Neurosci. 2013 Oct 01;7:624
pubmed: 24098281
Nat Genet. 2012 Apr 15;44(5):552-61
pubmed: 22504417
Cereb Cortex. 2004 Jan;14(1):11-22
pubmed: 14654453
Brain. 2013 Oct;136(Pt 10):3140-50
pubmed: 24014518
Neurology. 1998 Jul;51(1):78-84
pubmed: 9674783
Epilepsia. 2019 Jan;60(1):e1-e5
pubmed: 30324623
Annu Rev Clin Psychol. 2013;9:177-213
pubmed: 23297790
Brain. 2005 Aug;128(Pt 8):1818-31
pubmed: 15857932