Healthy Post-Menarchal Adolescent Girls Demonstrate Multi-Level Reproductive Axis Immaturity.

Adolescent Adolescent Development / physiology Adult Child Cohort Studies Estradiol Female Follicle Stimulating Hormone / blood Humans Hypothalamo-Hypophyseal System / metabolism Inhibins / blood Luteinizing Hormone / blood Menarche / physiology Menstrual Cycle / physiology Ovary / metabolism Ovulation / physiology Progesterone / blood

Journal

The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 14 03 2018
accepted: 01 10 2018
pubmed: 6 10 2018
medline: 18 12 2019
entrez: 6 10 2018
Statut: ppublish

Résumé

Menstrual irregularity after menarche has been attributed to immature estrogen positive feedback activity (E+FB) but data are conflicting. To determine the hypothalamic-pituitary-ovarian contributions to menstrual irregularity in adolescents. Twenty-three healthy girls [aged 12.8 to 17.6 years; 0.4 to 3.5 years postmenarche; body mass index (BMI) percentile, 41.0 to 99.3] underwent serial hormone measurements and pelvic ultrasounds during two consecutive menstrual cycles. Hormones and follicle growth were compared with 65 adult historic controls with ovulatory cycles (OVs). Girls had anovulatory cycles (ANOVs; 30%), OVs with a short luteal phase (short OVs; 22%), or OVs with normal luteal phase (normal OVs; 48%) without differences in cycle length, chronologic or gynecologic age, or BMI. Adolescents showed a spectrum of E+FB [midcycle LH adjusted for preovulatory estradiol (E2)]; only normal OV girls were comparable to adults. All OV girls had lower E2, progesterone, and gonadotropins during the luteal phase and luteal-follicular transition compared with adults. Normal OV girls also had lower follicular phase LH and FSH levels, a longer follicular phase, a slower dominant follicle growth rate, and smaller estimated preovulatory follicle size than adults. Follicular phase E2 and inhibin B levels were lower in normal OV girls than in adults even after adjusting for differences in FSH and follicle size. Early postmenarchal girls with normal OVs demonstrate mature E+FB but continue to have lower gonadotropin levels, diminished ovarian responsiveness, and decreased corpus luteum sex steroid synthesis compared with adults, indicating that reproductive axis maturity requires coordinated development of all components of the hypothalamic-pituitary-ovarian axis.

Identifiants

DOI: 10.1210/jc.2018-00595 PMID: 30289507 PMC: PMC6325170
pubmed: 30289507
pii: 5114466
doi: 10.1210/jc.2018-00595
pmc: PMC6325170
doi:

Substances chimiques

inhibin B 0
Progesterone 4G7DS2Q64Y
Estradiol 4TI98Z838E
Inhibins 57285-09-3
Luteinizing Hormone 9002-67-9
Follicle Stimulating Hormone 9002-68-0

Banques de données

ClinicalTrials.gov
['NCT02486757']

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

613-623

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD028934
Pays : United States
Organisme : NICHD NIH HHS
ID : R24 HD102061
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States

Références

Am J Obstet Gynecol. 1972 Oct 1;114(3):405-18
pubmed: 4637461
Clin Endocrinol (Oxf). 1990 Sep;33(3):333-44
pubmed: 2123756
J Clin Endocrinol Metab. 2004 Sep;89(9):4343-50
pubmed: 15356031
J Clin Endocrinol Metab. 1979 Oct;49(4):514-9
pubmed: 479344
Chronobiol Int. 1984;1(2):159-65
pubmed: 6600021
J Clin Endocrinol Metab. 1999 Jan;84(1):105-11
pubmed: 9920069
Steroids. 2013 Jan;78(1):96-101
pubmed: 23127814
J Clin Endocrinol Metab. 2008 Apr;93(4):1186-94
pubmed: 18252789
Pediatr Res. 1974 Aug;8(8):740-5
pubmed: 4844524
Fertil Steril. 1980 Aug;34(2):99-105
pubmed: 7409241
Hum Reprod. 2014 Mar;29(3):592-600
pubmed: 24357435
Fertil Steril. 2007 Dec;88(6):1625-31
pubmed: 17482608
Ann Hum Biol. 1984 Nov-Dec;11(6):495-508
pubmed: 6524865
Fertil Steril. 1988 Jul;50(1):1-15
pubmed: 3289975
Med Sci Sports Exerc. 2011 Aug;43(8):1575-81
pubmed: 21681120
J Clin Endocrinol Metab. 1982 Feb;54(2):241-6
pubmed: 6798063
J Clin Endocrinol Metab. 1983 Oct;57(4):792-6
pubmed: 6411753
Endocrinol Metab Clin North Am. 1993 Sep;22(3):491-505
pubmed: 8243444
J Clin Endocrinol Metab. 1995 May;80(5):1541-7
pubmed: 7744998
Pediatrics. 2015 Dec;136(6):1154-65
pubmed: 26598450
J Clin Endocrinol Metab. 1992 Apr;74(4):836-41
pubmed: 1548348
J Adolesc Health Care. 1986 Jul;7(4):236-44
pubmed: 3721946
Science. 1975 Oct 10;190(4210):161-3
pubmed: 1166307
Pediatr Res. 1972 Jan;6(1):18-25
pubmed: 5065355
J Clin Endocrinol Metab. 1986 Jun;62(6):1136-44
pubmed: 3084534
Hum Reprod. 2006 Jun;21(6):1442-52
pubmed: 16439502
Clin Endocrinol (Oxf). 2012 Oct;77(4):500-7
pubmed: 22702226
Fertil Steril. 1987 Jan;47(1):82-8
pubmed: 3098586
J Clin Endocrinol Metab. 1977 Aug;45(2):307-11
pubmed: 885995
Horm Res. 1986;24(4):269-79
pubmed: 3491030
Biol Reprod. 1982 Sep;27(2):354-61
pubmed: 7126735
J Clin Endocrinol Metab. 2015 Mar;100(3):1062-70
pubmed: 25490277
Fertil Steril. 2007 Nov;88(5):1404-7
pubmed: 17368453
Hum Reprod. 2004 Feb;19(2):383-92
pubmed: 14747186
J Clin Endocrinol Metab. 1973 Nov;37(5):714-8
pubmed: 4749445
J Clin Endocrinol Metab. 1992 Mar;74(3):600-7
pubmed: 1740493
Clin Obstet Gynaecol. 1983 Dec;10(3):603-20
pubmed: 6653032
J Biosoc Sci Suppl. 1978;(5):27-42
pubmed: 295058
Reprod Biol Endocrinol. 2008 Dec 10;6:61
pubmed: 19077200
Hum Reprod. 2014 Jan;29(1):97-106
pubmed: 24135076
Clin Chim Acta. 2008 Feb;388(1-2):99-105
pubmed: 18023274
J Clin Endocrinol Metab. 1983 Oct;57(4):797-802
pubmed: 6411754
Br J Obstet Gynaecol. 1980 Jul;87(7):613-8
pubmed: 7426518
J Clin Endocrinol Metab. 1978 Nov;47(5):944-54
pubmed: 122422
J Clin Endocrinol Metab. 2013 Sep;98(9):3572-83
pubmed: 23913942
Reprod Sci. 2018 Jan;25(1):33-38
pubmed: 29153058
J Am Med Assoc. 1949 Dec 17;141(16):1123-9, illust
pubmed: 15394678
Gynecol Obstet Invest. 2008;66(2):111-8
pubmed: 18446040
J Endocrinol. 1983 May;97(2):213-9
pubmed: 6854190
Fertil Steril. 1992 Oct;58(4):685-90
pubmed: 1426310
Clin Endocrinol (Oxf). 1980 Feb;12(2):107-20
pubmed: 6249519
J Steroid Biochem. 1984 Jan;20(1):231-6
pubmed: 6231419
Environ Health Perspect. 1996 Apr;104(4):408-13
pubmed: 8732951
Lancet. 1978 Nov 25;2(8100):1145-6
pubmed: 82698
Med Sci Monit. 2017 Oct 23;23:5041-5048
pubmed: 29056745
J Clin Invest. 1984 Jun;73(6):1638-47
pubmed: 6427277
Menopause. 2013 Nov;20(11):1169-75
pubmed: 23652031
J Clin Endocrinol Metab. 2000 Mar;85(3):1021-5
pubmed: 10720033
J Clin Endocrinol Metab. 2003 Oct;88(10):4682-8
pubmed: 14557441
Int J Gynaecol Obstet. 1988 Oct;27(2):249-53
pubmed: 2903093
Major Probl Obstet Gynecol. 1977;7:1-193
pubmed: 836520
Horm Res. 1980;12(1):46-62
pubmed: 6767650
Endocrinology. 1974 Jan;94(1):198-206
pubmed: 4202989
J Clin Endocrinol Metab. 1987 Apr;64(4):789-93
pubmed: 3818903

Auteurs

Bob Z Sun (BZ)

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio.

Tairmae Kangarloo (T)

Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Judith M Adams (JM)

Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Patrick M Sluss (PM)

Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Corrine K Welt (CK)

Department of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah.

Donald W Chandler (DW)

Endocrine Sciences, Laboratory Corp, Calabasas Hills, California.

David T Zava (DT)

ZRT Laboratory, Beaverton, Oregon.

John A McGrath (JA)

Social & Scientific Systems, Inc., Durham, North Carolina.

David M Umbach (DM)

Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Janet E Hall (JE)

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Natalie D Shaw (ND)

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adolescent › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Développement humain › Développement de l'adolescent › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Gonadotrophines hypophysaires › Hormone folliculostimulante › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Système nerveux › Système neuroendocrinien › Axe hypothalamohypophysaire › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Inhibines › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Gonadotrophines hypophysaires › Hormone lutéinisante › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › Ménarche › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle menstruel › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Système endocrine › Glandes endocrines › Gonades › Ovaire › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Ovulation › Healthy Post-Menarchal Adolescent Girls...
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Healthy Post-Menarchal Adolescent Girls...