Diltiazem Promotes Regenerative Axon Growth.

Amides / pharmacology Animals Axons / drug effects Calcium Channel Blockers / pharmacology Calcium Channels, L-Type / metabolism Chondroitin Sulfate Proteoglycans / metabolism Diltiazem / pharmacology Drug Synergism Ganglia, Spinal / drug effects Humans Mice, Inbred C57BL Nerve Regeneration / drug effects Pyridines / pharmacology Rats, Sprague-Dawley
Axon regeneration Chondroitin sulfate proteoglycans Cortical neurons Diltiazem Scrape assay Sensory neurons

Journal

Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 18 06 2018
accepted: 11 09 2018
pubmed: 21 9 2018
medline: 30 8 2019
entrez: 21 9 2018
Statut: ppublish

Résumé

Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were screened for cortical neuron axonal regrowth using an in vitro cortical scrape assay. Diltiazem, verapamil, and bromopride were discovered to facilitate axon regeneration in rat cortical cultures, in the presence of chondroitin sulfate proteoglycans (CSPGs). Diltiazem, an L-type calcium channel blocker (L-CCB), also promotes axon outgrowth in adult primary mouse dorsal root ganglion (DRG) and induced human sensory (iSensory) neurons.

Identifiants

DOI: 10.1007/s12035-018-1349-5 PMID: 30232777 PMC: PMC6424671
pubmed: 30232777
doi: 10.1007/s12035-018-1349-5
pii: 10.1007/s12035-018-1349-5
pmc: PMC6424671
mid: NIHMS1507586
doi:

Substances chimiques

Amides 0
Calcium Channel Blockers 0
Calcium Channels, L-Type 0
Chondroitin Sulfate Proteoglycans 0
Pyridines 0
Y 27632 138381-45-0
Diltiazem EE92BBP03H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3948-3957

Subventions

Organisme : NEI NIH HHS
ID : U01 EY027256
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS042304
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007205
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS033020
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS039962
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007473
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097283
Pays : United States

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Auteurs

Eric A Huebner (EA)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.

Stéphane Budel (S)

Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.

Zhaoxin Jiang (Z)

Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.

Takao Omura (T)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Tammy Szu-Yu Ho (TS)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Lee Barrett (L)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Janie S Merkel (JS)

Yale Center for Molecular Discovery, Yale University, West Haven, CT, 06516, USA.

Luis M Pereira (LM)

Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Nick A Andrews (NA)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Xingxing Wang (X)

Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.

Bhagat Singh (B)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Kush Kapur (K)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Michael Costigan (M)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Stephen M Strittmatter (SM)

Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA. stephen.strittmatter@yale.edu.

Clifford J Woolf (CJ)

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. clifford.woolf@childrens.harvard.edu.
ORCID: 0000-0001-9840-596X

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Classifications MeSH

Recherchemedicale.com › Composés chimiques organiques › Amides › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Eucaryotes › Animaux › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Cellules › Neurones › Neurofibres › Axones › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéoglycanes › Protéoglycanes à chondroïtine sulfate › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Diltiazem › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Synergie des médicaments › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diltiazem Promotes Regenerative Axon Growth.
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Recherchemedicale.com › Phénomènes biologiques › Régénération › Régénération nerveuse › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Diltiazem Promotes Regenerative Axon Growth.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Diltiazem Promotes Regenerative Axon Growth.