High-Dose Human Milk Feedings Decrease Oxidative Stress in Premature Infant.
human milk
oxidative stress
premature infants
Journal
JPEN. Journal of parenteral and enteral nutrition
ISSN: 1941-2444
Titre abrégé: JPEN J Parenter Enteral Nutr
Pays: United States
ID NLM: 7804134
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
12
01
2018
accepted:
29
03
2018
pubmed:
16
5
2018
medline:
18
8
2020
entrez:
16
5
2018
Statut:
ppublish
Résumé
Premature infants are susceptible to oxidative stress, increasing the risk for serious morbidities. High-dose human milk (HM) feedings decrease morbidity risks and may reduce oxidative stress in this population. The purpose of this study was to compare oxidative stress using serial urinary F This was a quasi-experimental design that categorized 22 premature infants into mutually exclusive comparison groups based on exposure to HM and PF. Serial urine samples (before and after first feeding, and DOL 7, 14, and 21) were used to determine urine F Comparing the predominantly HM-fed and predominantly PF-fed groups over time, median F Our results demonstrate that predominantly HM feedings were associated with decreased oxidative stress, whereas PF feedings increased oxidative stress in premature infants, even after controlling for perinatal oxidant exposures of HMF or PF introduction.
Sections du résumé
BACKGROUND
Premature infants are susceptible to oxidative stress, increasing the risk for serious morbidities. High-dose human milk (HM) feedings decrease morbidity risks and may reduce oxidative stress in this population. The purpose of this study was to compare oxidative stress using serial urinary F
METHODS
This was a quasi-experimental design that categorized 22 premature infants into mutually exclusive comparison groups based on exposure to HM and PF. Serial urine samples (before and after first feeding, and DOL 7, 14, and 21) were used to determine urine F
RESULTS
Comparing the predominantly HM-fed and predominantly PF-fed groups over time, median F
CONCLUSIONS
Our results demonstrate that predominantly HM feedings were associated with decreased oxidative stress, whereas PF feedings increased oxidative stress in premature infants, even after controlling for perinatal oxidant exposures of HMF or PF introduction.
Substances chimiques
F2-Isoprostanes
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126-132Subventions
Organisme : Academy of Nutrition and Dietetics Foundation
ID : Academy of Nutrition and Dietetics Foundation 2016
Pays : International
Organisme : Rush University
ID : Rush University 2008 Pilot Project Grant
Pays : International
Informations de copyright
© 2018 American Society for Parenteral and Enteral Nutrition.