Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis.
cancer
disease
disease type
epidemiology
organ system
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
14
03
2018
revised:
15
03
2018
accepted:
18
03
2018
pubmed:
20
4
2018
medline:
13
11
2019
entrez:
20
4
2018
Statut:
ppublish
Résumé
To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.
Identifiants
pubmed: 29669820
pii: oemed-2018-105131
doi: 10.1136/oemed-2018-105131
pmc: PMC6581104
doi:
Substances chimiques
Plastics
0
Styrenes
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-162Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Occup Environ Med. 2015 Mar;72(3):165-70
pubmed: 25358742
IARC Monogr Eval Carcinog Risks Hum. 2002;82:1-556
pubmed: 12687954
Epidemiology. 2013 Mar;24(2):195-203
pubmed: 23344212
J Occup Environ Med. 2009 Nov;51(11):1314-25
pubmed: 19858743
Scand J Work Environ Health. 1987 Apr;13(2):94-9
pubmed: 3602970
Scand J Work Environ Health. 1982 Dec;8(4):250-9
pubmed: 7170621
Scand J Work Environ Health. 1992 Jun;18(3):145-54
pubmed: 1615288
Int Arch Occup Environ Health. 1993;65(2):89-95
pubmed: 8253516
IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt F):9-562
pubmed: 23189753
Epidemiology. 2017 Mar;28(2):300-310
pubmed: 27984421
Environ Health Perspect. 1990 Jun;86:107-17
pubmed: 2401250
Occup Health Saf. 2006 Dec;75(12):60, 62-3, 65
pubmed: 17216777
Am J Ind Med. 1985;8(3):193-205
pubmed: 4050802
Scand J Work Environ Health. 1994 Aug;20(4):272-8
pubmed: 7801072
Occup Environ Med. 2006 Oct;63(10):707-12
pubmed: 16757507
Am J Ind Med. 2017 Jul;60(7):651-657
pubmed: 28616886
Am J Ind Med. 1990;17(5):593-606
pubmed: 2337083
Occup Environ Med. 2005 May;62(5):325-9
pubmed: 15837854
Scand J Work Environ Health. 1994 Aug;20(4):251-61
pubmed: 7801070
Rep Carcinog. 2011;12:iii-499
pubmed: 21822324
Occup Environ Med. 2010 Jan;67(1):67-71
pubmed: 20029026
J Occup Med. 1980 Jul;22(7):445-60
pubmed: 7411258
Br J Ind Med. 1990 Nov;47(11):753-62
pubmed: 2245187
Scand J Work Environ Health. 1985 Oct;11(5):347-52
pubmed: 4070999
Occup Environ Med. 2016 Feb;73(2):97-102
pubmed: 26574575
Scand J Work Environ Health. 1978;4 Suppl 2:247-52
pubmed: 734411
J Occup Environ Med. 2009 Nov;51(11):1326-32
pubmed: 19858739